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Abstract Background Chile Crece Contigo (ChCC) is defined as a comprehensive, intersectoral, and multicomponent policy that aims to help all children reach their full potential for development, regardless of their socio‐economic ...
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Abstract Background Chile Crece Contigo (ChCC) is defined as a comprehensive, intersectoral, and multicomponent policy that aims to help all children reach their full potential for development, regardless of their socio‐economic status. Methods This case study was developed on the basis of grey literature review and key informants' interviews. Results ChCC behaves as a complex adaptive system that combines universal and targeted benefits for the more vulnerable starting since gestation and until the children are 4?years old. Three key ministries are involved in ChCC management: health, education, and social development. Studies show adequate programme implementation and positive effects of ChCC on child development. In addition, it was found that the more families use ChCC benefits and the longer the subsystem has been operating in the commune, the greater the positive effects. Conclusions Strong political support based on principles of equity and child rights combined with strong evidence and funding commitment from government has been central to emergence, scaling up, and sustainability of ChCC. Further sustainability of ChCC will rely on firmly establishing a well‐trained and compensated cadre of early child development professionals and paraprofessionals as well as an improved management and evaluation decentralized system.
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? 2023 Elsevier B.V.In this study, a new Schiff base (H2L), which has not been recorded in the literature, and its metal complexes with general formula [ML].(H2O) [M: Cu(II) and Mn(II)] were synthesized and their structures were e...
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? 2023 Elsevier B.V.In this study, a new Schiff base (H2L), which has not been recorded in the literature, and its metal complexes with general formula [ML].(H2O) [M: Cu(II) and Mn(II)] were synthesized and their structures were elucidated. Techniques such as 1H- and 13C-NMR, FT-IR, UV–vis, TG-DTG, molar conductivity, magnetic susceptibility, ICP-OES, and elemental analysis were used to characterize the structures of the Schiff base and metal complexes. According to the analysis's findings, the complexes' metal:ligand ratio was 1:1. Additionally, the 6-311G(d,p) and LANL2DZ basis sets of the DFT/B3LYP method were used to calculate the optimized molecular geometries of the H2L and its metal complexes, respectively. Additionally, the synthesized compounds' molecular electrostatic potential (MEP) diagrams, frontier molecular orbitals (HOMO-LUMO), chemical shift values for the 1H- and 13C-NMR, vibrational frequencies, and wavelengths of electronic transitions were all determined. Experimentally obtained results were verified with theoretical data that matched well. [CuL].(H2O) and [MnL].(H2O) were examined for their catalase-like and catecholase-like enzymatic activities using volumetric and spectrophotometric techniques, respectively. For this objective, the catalytic activities of the synthesized molecules in the disproporsion reaction of H2O2 in the presence of 1-methylimidazole and the oxidation reaction of 3,5-di-tert-butylcatechol to 3,5-di-tert-butylquinone in aerobic medium were investigated. According to the enzyme-like studies, [MnL].(H2O) was more catalytically active than [CuL].(H2O) in both of the mentioned reactions.
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